The development of the autonomic nervous control of the cardiorespiratory system will be studied at the biochemical level. Measurements will be made of levels of the enzymes of catecholamine metabolism in autopsied human tissues including heart, brain, laryngeal muscle, and carotid and aortic bodies. Attempts will be made to evaluate the functional maturity of the autonomic nervous control of the cardiorespiratory system in infants from these data. In addition, tissues from infants having died of Suddent Infant Death Syndrome (SIDS) will be analyzed to test the hypothesis that these infants die of an autonomic disease which may be reflected at the biochemical level. These data will also yield information about the sympathetic innervation of the heart and other tissues and about the development of sympathetic innervation of the heart postnatally.